Structure of Methazolamide
Methazolamide is a thiazide-like carbonic anhydrase inhibitor with a central sulfonamide group attached to a benzene ring and a thiazole moiety.
Chemical Formula: C₅H₇N₃O₃S₂
Mode of Action
Carbonic Anhydrase Inhibition: Similar to acetazolamide, methazolamide inhibits carbonic anhydrase, reducing bicarbonate reabsorption in the kidneys.
Renal Effects: Increases excretion of bicarbonate, sodium, potassium, and water, leading to diuresis.
Metabolic Acidosis: Induces a mild metabolic acidosis by lowering blood bicarbonate levels.
Uses
Glaucoma: Decreases intraocular pressure by reducing aqueous humor formation.
Altitude Sickness: Prevents acute mountain sickness through diuretic effects.
Epilepsy: Used as an adjunctive therapy for seizure control.
Diuretic: Employed in cases requiring carbonic anhydrase inhibition.