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Adrenal glands

  • The adrenal glands are small, triangular-shaped glands located on top of both kidneys.

  • They are part of the body’s endocrine system, producing hormones that are vital for life.

human adrenal glands

Here are the illustrations of the human adrenal glands.

  • Each adrenal gland is structurally and functionally divided into two main parts: the adrenal cortex and the adrenal medulla, each responsible for producing different sets of hormones.

Structure

1. Adrenal Cortex: 

  • The outer section of the gland, makes up the bulk of the adrenal gland.

  • It is divided into three zones: the zona glomerulosa, the zona fasciculata, and the zona reticularis. Each zone produces different types of hormones.

2. Adrenal Medulla: 

  • The inner section of the gland, which produces adrenaline (epinephrine) and noradrenaline (norepinephrine).

Function of Adrenal glands

I.   Adrenal Cortex:

  • Aldosterone: Regulates blood pressure and electrolyte balance.

  • Cortisol: Controls metabolism, immune response, and stress.

  • Androgens: Precursors to sex hormones, influencing sexual development.

II.   Adrenal Medulla:

  • Adrenaline and Noradrenaline: Increase heart rate, blood pressure, and blood sugar for emergency "fight or flight" responses.

Disorders of Adrenal glands

  1. Addison's Disease: Insufficient cortisol and aldosterone, leading to fatigue, weight loss, and low blood pressure. Often autoimmune.

  2. Cushing's Syndrome: Excess cortisol, causing weight gain, high blood pressure, and osteoporosis. Often due to tumors or corticosteroid use.

  3. Primary Hyperaldosteronism (Conn's Syndrome): Excess aldosterone causing high blood pressure and low potassium, often from a benign tumor.

  4. Pheochromocytoma: A rare tumor of the adrenal medulla causing excessive catecholamines, leading to severe hypertension and rapid heart rate.

  5. Adrenal Cancer: Malignant tumors that may cause hormone overproduction, mimicking other adrenal disorders.

Treatment of Adrenal glands

  • Medications: To replace deficient hormones (e.g., hydrocortisone for Addison's) or control excess hormones (e.g., mitotane for adrenal cancer).

  • Surgery: To remove tumors.

  • Management: Ongoing monitoring and symptom management for hormone balance.


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