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Advantages & Disadvantages of Mucosal Drug Delivery system

Advantages of Mucosal Drug Delivery system:

1. Targeted Delivery Mucosal Drug Delivery system:

  • NDDS can provide targeted drug delivery, enhancing therapeutic effects while minimizing side effects.

2. Improved Bioavailability:

  • Bypassing certain barriers or utilizing absorption enhancers can improve drug absorption.

3. Prolonged Drug Release:

  • Mucoadhesive systems can stay attached to mucosal surfaces for extended durations, allowing sustained drug release.

4. Bypass First-Pass Metabolism:

  • Especially in oral mucosal delivery, direct absorption into systemic circulation can avoid the first-pass effect in the liver.

5. Patient Compliance:

  • Reduced dosing frequency and potentially less invasive routes improve patient comfort and adherence.

Disadvantages of Mucosal Drug Delivery system:

1. Complex Formulation:

  • Designing and formulating these systems can be technically challenging.

2. Stability Issues:

  • Some drugs might be unstable in the mucosal environment due to pH or enzymatic activity.

3. Variable Absorption:

  • Differences in mucosal conditions among individuals can lead to variable drug absorption.

4. Mucus Renewal:

  • Continuous mucus turnover can lead to reduced residence time for some drug delivery systems.

5. Potential Irritation:

  • Some formulations might irritate mucosal tissues.

Advantages and Disadvantages of mucosal drug delivery system
Advantages and Disadvantages of mucosal drug delivery system


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