Advantages of Mucosal Drug Delivery system:
1. Targeted Delivery Mucosal Drug Delivery system:
NDDS can provide targeted drug delivery, enhancing therapeutic effects while minimizing side effects.
2. Improved Bioavailability:
Bypassing certain barriers or utilizing absorption enhancers can improve drug absorption.
3. Prolonged Drug Release:
Mucoadhesive systems can stay attached to mucosal surfaces for extended durations, allowing sustained drug release.
4. Bypass First-Pass Metabolism:
Especially in oral mucosal delivery, direct absorption into systemic circulation can avoid the first-pass effect in the liver.
5. Patient Compliance:
Reduced dosing frequency and potentially less invasive routes improve patient comfort and adherence.
Disadvantages of Mucosal Drug Delivery system:
1. Complex Formulation:
Designing and formulating these systems can be technically challenging.
2. Stability Issues:
Some drugs might be unstable in the mucosal environment due to pH or enzymatic activity.
3. Variable Absorption:
Differences in mucosal conditions among individuals can lead to variable drug absorption.
4. Mucus Renewal:
Continuous mucus turnover can lead to reduced residence time for some drug delivery systems.
5. Potential Irritation:
Some formulations might irritate mucosal tissues.
