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Amiloride

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Structure of Amiloride

  • Amiloride is a non-steroidal potassium-sparing diuretic with a benzothiadiazine core fused to a pyridine ring, containing amine groups.

  • Chemical Formula: C₄H₇N₄O₃S₂

Structure of Amiloride
Structure of Amiloride

Mode of Action

  • ENaC Inhibition: Blocks epithelial sodium channels (ENaC) in the collecting ducts, reducing sodium reabsorption.

  • Potassium Retention: Minimizes potassium excretion by antagonizing sodium reabsorption.

  • Sodium Excretion: Promotes diuresis by increasing sodium and water excretion without significant potassium loss.

Uses

  1. Edema: Manages fluid retention in congestive heart failure and renal disease.

  2. Hypertension: Lowers blood pressure by promoting sodium excretion.

  3. Heart Failure: Reduces fluid overload and prevents hypokalemia when used with other diuretics.

  4. Hyperaldosteronism: Treats conditions with excess aldosterone production.ss.


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