Amlodipine

Structure of Amlodipine

• Amlodipine is a dihydropyridine calcium channel blocker with a substituted phenyl ring and an ethyl group attached to the dihydropyridine core.

• Chemical Formula: C₂₀H₂₄N₂O₅

Structure of Amlodipine

Mode of Action

• Calcium Channel Blocking: Inhibits L-type calcium channels predominantly in vascular smooth muscle.

• Vasodilation: Causes peripheral arterial dilation, reducing blood pressure and cardiac workload.

• Prolonged Action: Long half-life allows once-daily dosing with sustained effects.

Uses

1. Hypertension: Lowers blood pressure effectively with minimal side effects.

2. Angina Pectoris: Prevents and alleviates chest pain by improving myocardial oxygen supply.

3. Coronary Artery Disease: Enhances coronary blood flow.

4. Prevention of Stroke: Indirectly reduces stroke risk by controlling hypertension.