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Amphotericin B: Chemical Structure, Mechanism of Action, Uses & Side effect

Chemical formula:

  • C47H73NO17

Structure of Amphotericin B
Structure of Amphotericin B

Mechanism of action:

  • Amphotericin B binds to ergosterol, a major component of fungal cell membranes. This binding creates pores in the membrane, causing leakage of essential cellular contents and ultimately leading to fungal cell death.

Uses:

  • Amphotericin B is used to treat severe systemic fungal infections, including cryptococcal meningitis, invasive candidiasis, and various mold infections.

Side effects:

  • Common side effects include fever, chills, nausea, vomiting, and kidney toxicity. Infusion-related reactions, such as shaking and hypotension, may also occur.



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