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Anisindione

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Structure

  • Anisindione is a synthetic derivative of indione with aromatic substitutions enhancing its anticoagulant properties.

  • Chemical Formula: C₁₅H₁₅NO₄S

    Chemical formula of Anisindione
Structure of Anisindione
Structure of Anisindione

Mode of Action

  • Vitamin K Epoxide Reductase Inhibition: Similar to warfarin, anisindione  inhibits the enzyme responsible for regenerating reduced vitamin K.

  • Coagulation Factor Inhibition: Reduces synthesis of vitamin K-dependent clotting factors II, VII, IX, and X.

  • Anticoagulant Effect: Prolongs clotting times, preventing thrombosis and embolism.

Uses of Anisindione

  • Thromboembolic Disorders: Prevents and treats deep vein thrombosis (DVT), pulmonary embolism (PE), and stroke.

  • Atrial Fibrillation: Reduces stroke risk by preventing clot formation.

  • Mechanical Heart Valves: Prevents thrombus development on artificial valves.

  • Myocardial Infarction: Lowers the risk of recurrent heart attacks by inhibiting clot formation.


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