Introduction
Antimicrobials are agents that kill microorganisms or inhibit their growth, playing a critical role in treating and preventing infections in humans, animals, and plants.
This group includes antibiotics, antivirals, antifungals, and antiparasitics, each with varying mechanisms of action depending on the type of microorganism they target.
Mechanism of Action
Antimicrobials act through various mechanisms to exert their effects on microorganisms:
1) Inhibition of Cell Wall Synthesis:
Antibiotics like penicillin and cephalosporins target bacterial cell walls, essential for bacterial integrity and survival.
Inhibiting cell wall synthesis causes bacteria to burst and die.
2) Inhibition of Protein Synthesis:
Antibiotics such as tetracyclines and macrolides bind to bacterial ribosomes, interfering with protein production necessary for bacterial growth and function.
3) Alteration of Cell Membranes:
Antifungals like amphotericin B bind to components of fungal cell membranes, increasing permeability and causing leakage of cellular contents.
4) Inhibition of Nucleic Acid Synthesis:
Drugs like quinolones and rifampicin interfere with DNA or RNA synthesis, crucial for bacterial replication and transcription.
5) Antimetabolites:
Sulfonamides act as antimetabolites by mimicking and thus inhibiting folate synthesis, a vital process for bacterial DNA synthesis and replication.
6) Interference with Pathogen Metabolism:
Some antimicrobials disrupt specific biochemical pathways important for the microorganism's energy production or replication.
Classification of Antimicrobials
Antimicrobials are classified based on the type of organisms they act against, their chemical structure, and their mechanism of action.
1) Antibiotics:
Specifically target bacteria.
A. Broad-spectrum: Effective against a wide range of bacteria.
B. Narrow-spectrum: Effective against specific types of bacteria.
2) Antivirals:
Target viruses.
Categorized based on the stage of the viral life cycle they affect, such as viral entry inhibitors or nucleoside analogs that inhibit viral replication.
3) Antifungals:
Used against fungal infections.
Include classes like polyenes, azoles, and echinocandins, differing in their mechanisms of action.
4) Antiparasitics:
Target parasitic infections caused by organisms like protozoa and helminths.
Examples include metronidazole for Giardia infections and mebendazole for worm infections.
This comprehensive approach to antimicrobials highlights their mechanisms of action a