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Antipsychotics: Typical Antipsychotics (First-Generation) & Atypical Antipsychotics (Second-Generation)

  • Antipsychotic drugs, also known as neuroleptic medications, can be classified into two main categories based on their chemical structure and pharmacological properties: typical (first-generation) antipsychotics and atypical (second-generation) antipsychotics.

1.Typical Antipsychotics (First-Generation):

A.Phenothiazines:

  • Chlorpromazine hydrochloride

  • Triflupromazine

  • Thioridazine hydrochloride

  • Piperacetazine hydrochloride

  • Promazine hydrochloride

  • Prochlorperazine maleate

  • Trifluoperazine hydrochloride


2.Atypical Antipsychotics (Second-Generation):

B.Ring Analogues of Phenothiazines:

  • Clozapine

  • Loxapine succinate

  • Chlorprothixene

  • Thiothixene


C.Fluorobutyrophenones:

  • Haloperidol

  • Droperidol

  • Risperidone


D.Beta Amino Ketones:

  • Molindone hydrochloride


E.Benzamides:

  • Sulpiride

Antipsychotic Drugs
Antipsychotic Drugs
  • Atypical antipsychotics are often considered a newer generation of drugs and are generally preferred over typical antipsychotics due to their potentially lower risk of causing extrapyramidal side effects (movement disorders).

  • However, the choice of antipsychotic medication depends on individual patient characteristics and the specific mental health condition being treated.

  • Treatment decisions should always be made by a qualified healthcare provider based on a patient's unique needs and medical history.

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