Antipsychotics: Typical Antipsychotics (First-Generation) & Atypical Antipsychotics (Second-Generation)

• Antipsychotic drugs, also known as neuroleptic medications, can be classified into two main categories based on their chemical structure and pharmacological properties: typical (first-generation) antipsychotics and atypical (second-generation) antipsychotics.

1.Typical Antipsychotics (First-Generation):

A.Phenothiazines:

• Chlorpromazine hydrochloride

• Triflupromazine

• Thioridazine hydrochloride

• Piperacetazine hydrochloride

• Promazine hydrochloride

• Prochlorperazine maleate

• Trifluoperazine hydrochloride

2.Atypical Antipsychotics (Second-Generation):

B.Ring Analogues of Phenothiazines:

• Clozapine

• Loxapine succinate

• Chlorprothixene

• Thiothixene

C.Fluorobutyrophenones:

• Haloperidol

• Droperidol

• Risperidone

D.Beta Amino Ketones:

• Molindone hydrochloride

E.Benzamides:

• Sulpiride

Antipsychotic Drugs

• Atypical antipsychotics are often considered a newer generation of drugs and are generally preferred over typical antipsychotics due to their potentially lower risk of causing extrapyramidal side effects (movement disorders).

• However, the choice of antipsychotic medication depends on individual patient characteristics and the specific mental health condition being treated.

• Treatment decisions should always be made by a qualified healthcare provider based on a patient's unique needs and medical history.