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Applications of Affinity Chromatography

Protein Purification:

  • Purification of monoclonal and polyclonal antibodies using Protein A or G.

  • Isolation of enzymes or recombinant proteins with affinity tags (e.g., His-tag, GST-tag).

Isolation of Biomolecules:

  • Separation of nucleic acids using immobilized complementary strands or aptamers.

  • Purification of carbohydrate-binding proteins or glycoproteins using lectin affinity chromatography.

Biomolecular Interaction Studies:

  • Studying binding kinetics and specificity between ligands and their targets.

  • Identifying unknown binding partners by capturing the protein of interest and then analyzing what co-elutes.


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