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Applications of Gel chromatography

  • Gel chromatography is widely used in various fields, notably the pharmaceutical industry:

Protein Purification:

  • Separates proteins by size without denaturing them, crucial for therapeutic protein production.

Molecular Weight Determination:

  • Using calibration standards, it can estimate the molecular weight of unknown molecules.

Nucleic Acid Separation:

  • Purifies DNA or RNA fragments and separates them based on size.

Polysaccharide Analysis:

  • Characterizes carbohydrates, useful in drug formulations or as therapeutic molecules.

Desalting and Buffer Exchange:

  • Removes salts and small impurities from samples while preserving larger biomolecules.

Drug Delivery Research:

  • Analyzes nanoparticle size distributions, aiding in understanding and optimizing drug carriers.

Fragmentation Studies:

  • Examines degradation patterns of large biomolecules into smaller fragments.

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