GRDDS stands for "Gastro-Retentive Drug Delivery Systems.
" It's a strategy in pharmaceutical sciences to prolong and control the release of drugs in the stomach, ensuring an extended period of drug release in the gastric region.
The primary rationale behind GRDDS is to improve the bioavailability and therapeutic efficacy of drugs with a narrow absorption window in the upper part of the gastrointestinal tract.
Here are some of the approaches used to achieve gastro-retention:
Overall Considerations and Challenges:
Safety and Comfort: Ensuring that these systems do not cause discomfort, obstruction, or harm to the patient is crucial.
Variable Gastric Emptying Time: The retention efficacy can be influenced by factors such as meal intake, posture, and individual variability.
Formulation Stability: The stability of the formulation under gastric conditions is important for the effectiveness of the delivery system.
Each GRDDS approach has its strengths and limitations, and the choice of system depends on the drug's physicochemical properties, therapeutic index, and the desired release profile. These systems offer innovative solutions for enhancing the efficacy and bioavailability of drugs with specific needs in terms of absorption and stability in the gastrointestinal tract.