Aspirin

MOA of Aspirin:

• Irreversibly inhibits COX-1 and COX-2, blocking prostaglandin and thromboxane A2 synthesis, reducing pain, inflammation, fever, and platelet aggregation Structure of

Structure of Aspirin

Pharmacological Actions:

• Anti-inflammatory

• Analgesic (pain relief)

• Antipyretic (fever reduction)

• Antiplatelet (prevents clotting)

Pharmacokinetics:

• Absorption: Rapid via stomach and intestine.

• Metabolism: Liver (to salicylic acid).

• Excretion: Urine, with dose-dependent kinetics.

Adverse Effects:

• GI issues: Ulcers, bleeding.

• Bleeding risk: Prolonged clotting time.

• Renal injury, hypersensitivity, tinnitus.

• Reye’s syndrome (in children with viral infections).