Chemical formula:
C22H19ClO3
![Structure of Atovaquone](https://static.wixstatic.com/media/c7082f_7c56bf8b538442a9997da16ca52d70c5~mv2.png/v1/fill/w_980,h_903,al_c,q_90,usm_0.66_1.00_0.01,enc_auto/c7082f_7c56bf8b538442a9997da16ca52d70c5~mv2.png)
Mechanism of action:
Atovaquone inhibits the mitochondrial electron transport chain in the Plasmodium parasite, specifically targeting the cytochrome bc1 complex.
This action disrupts the production of ATP, leading to the death of the parasite.
Uses:
Atovaquone is used in combination with proguanil (Malarone®) for the prevention and treatment of uncomplicated P. falciparum malaria, particularly in areas with drug-resistant strains.
It is also used in combination with other drugs for the treatment and prevention of Pneumocystis jirovecii pneumonia (PCP) in patients with HIV/AIDS
Side effects:
Nausea
Vomiting
Diarrhea
abdominal pain
headache
dizziness
and rash
serious side effects include hepatotoxicity, severe skin reactions, and anaemia.