Structure of Benazepril hydrochloride
Benazepril hydrochloride is a prodrug ACE inhibitor with a benzimidazole core and a carbamate moiety.
Chemical Formula: C₂₀H₃₄N₅O₆S·HCl
Mode of Action
Prodrug Activation: Metabolized to benazeprilat, the active form.
ACE Inhibition: Prevents conversion of angiotensin I to angiotensin II, reducing vasoconstriction.
Vasodilation: Leads to decreased systemic vascular resistance and blood pressure.
Renal Protection: Reduces progression of renal disease in hypertensive and diabetic patients.
Uses
Hypertension: Lowers blood pressure effectively with once-daily dosing.
Heart Failure: Improves symptoms and reduces mortality when used with other heart failure medications.
Diabetic Nephropathy: Protects against kidney damage in diabetic individuals.
Post-Myocardial Infarction: Aids in preventing adverse cardiac remodeling and improving survival.