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Benoxinate (Oxybuprocaine)

Structure

  • Benoxinate is an amino benzoic acid derivative with a butyl ester group, primarily used in ophthalmic preparations for its local anesthetic properties.

  • Chemical Formula: C₁₂H₂₀N₂O₂

    Formula of Benoxinate
Structure of Benoxinate
Structure of Benoxinate

Mode of Action

  • Sodium Channel Inhibition: Blocks voltage-gated sodium channels in corneal nerves, preventing pain signal transmission.

  • Membrane Stabilization: Reduces nerve excitability by stabilizing nerve membranes.

Uses

  • Ophthalmic Anesthesia: Applied as eye drops to numb the cornea before eye surgeries, injections, or diagnostic procedures.

  • Minor Eye Procedures: Used in non-surgical interventions requiring temporary corneal numbing.

Side Effects

  • Local Irritation: May cause eye redness, stinging, or discomfort.

  • Systemic Absorption: Minimal, but potential for allergic reactions in sensitive individuals.


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