Structure of Bepridil Hydrochloride
Bepridil hydrochloride is a benzothiazepine derivative with a phenyl ring attached to a thiazepine ring containing multiple substituents.
Chemical Formula: C₂₅H₃₈ClN₃OS
Mode of Action
Calcium Channel Blocking: Inhibits L-type calcium channels in cardiac and vascular smooth muscle.
Vasodilation: Causes relaxation of vascular smooth muscle, reducing blood pressure.
Antiarrhythmic Effects: Prolongs refractory periods and suppresses abnormal heart rhythms.
Other Effects: Exhibits anti-anginal and antiarrhythmic properties.
Uses
Hypertension: Lowers blood pressure through vasodilation.
Angina Pectoris: Reduces myocardial oxygen demand and alleviates chest pain.
Arrhythmias: Manages various cardiac arrhythmias.
Coronary Artery Disease: Improves coronary blood flow.