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Betamethasone

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Structure

  • Betamethasone is a potent synthetic glucocorticoid with a cyclopentanoperhydrophenanthrene structure, featuring fluorine substitutions that enhance its anti-inflammatory activity.

  • Chemical Formula: C₂₁H₂₉FO₅

    Formula of Betamethasone
Structure of Betamethasone
Structure of Betamethasone

Mode of Action

  • Glucocorticoid Activity: Activates glucocorticoid receptors, regulating gene expression involved in inflammation and immune response.

  • Anti-Inflammatory Effects: Inhibits pro-inflammatory cytokines and mediators, reducing inflammation.

  • Immunosuppression: Suppresses immune cell activity, mitigating autoimmune and hypersensitivity reactions.

  • Metabolic Regulation: Influences glucose metabolism and protein synthesis, affecting energy balance and tissue repair.

Uses of Betamethasone

  • Inflammatory and Autoimmune Diseases: Treats rheumatoid arthritis, lupus, and inflammatory bowel disease by reducing inflammation and suppressing the immune system.

  • Allergic Reactions: Manages severe allergic responses and anaphylaxis.

  • Skin Conditions: Applied topically to alleviate dermatitis, eczema, and psoriasis.

  • Respiratory Conditions: Used in asthma and chronic obstructive pulmonary disease (COPD) to control airway inflammation.

  • Endocrine Disorders: Replaces deficient cortisol in adrenal insufficiency.


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