Buclizine hydrochloride

Structure (Buclizine hydrochloride)

• Buclizine hydrochloride contains a piperazine ring bonded to a diphenylmethyl group with an ethyl substituent. The hydrochloride salt improves solubility.

• Chemical Formula: C₂₁H₂₈ClN₃·HCl

Structure Buclizine hydrochloride

Mode of Action

• Acts as an H₁-receptor antagonist with anticholinergic and antiemetic properties.

• It reduces histamine-induced symptoms and prevents nausea.

Uses

1. Motion Sickness: Prevents and treats nausea and vomiting related to travel.

2. Vertigo: Provides relief from dizziness associated with vestibular disorders.