Buy Now the Hard Copy of notes for seamless and ad-free learning, Click Below!
Buffered Isotonic Solutions are specially formulated liquids that match the osmotic pressure of the body's natural fluids, such as blood and tears.
Additionally, they incorporate buffering systems to maintain a stable pH environment.
These solutions are crucial in pharmaceutical applications to ensure that when administered—whether through ophthalmic (eye) or intravenous (IV) routes—they are both compatible with body tissues and comfortable for the patient.
Types of Buffered Isotonic Solutions
Isotonic Solutions
Solute concentration matches body fluids, no net water movement.
Example: Normal saline (0.9% NaCl).
Hypotonic Solutions
Lower solute concentration: water moves into cells, causing swelling.
Example: 0.45% NaCl (half-normal saline).
Hypertonic Solutions
Higher solute concentration: water moves out, causing cells to shrink.
Example: 3% NaCl.
Key Characteristics
Isotonicity: Matches the osmotic pressure of body fluids to prevent cell damage.
Buffering Capacity: Maintains a consistent pH to ensure stability and compatibility with bodily tissues.
Importance in Pharmaceuticals
Buffered isotonic solutions are widely used in:
Ophthalmic Solutions: To ensure eye comfort and prevent irritation.
Intravenous Solutions: To safely deliver medications and fluids without causing hemolysis or cellular shrinkage.
Buy Now the Hard Copy of notes for seamless and ad-free learning, Click Below!