Structure
Bumetanide Chemical Structure – C17H20N2O5S
Mode of action
It produces a diuretic effect by competitively inhibiting sodium-potassium-chloride cotransporters in the nephron and blocking the transport of sodium ions during reabsorption.
Due to this inhibition, more water, sodium, chloride, magnesium, calcium, hydrogen, and potassium ions are excreted.
Uses
Edema, hepatic and nephrotic syndrome, renal disease are all conditions that are treated with bumetanide.