Structure of Bumetanide
Bumetanide is a loop diuretic similar to furosemide but with a more potent diuretic effect due to structural modifications.
Chemical Formula: C₁₄H₂₄BrN₃O₅S
Mode of Action
Loop of Henle Inhibition: Blocks the Na⁺/K⁺/2Cl⁻ symporter in the ascending limb of the loop of Henle.
Sodium, Potassium, Chloride Excretion: Promotes significant diuresis by increasing excretion of these ions.
Calcium and Magnesium Retention: Enhances reabsorption of calcium and magnesium, reducing the risk of kidney stones.
Uses
Edema: Manages edema associated with congestive heart failure, renal disease, and liver cirrhosis.
Hypertension: Lowers blood pressure by reducing blood volume.
Hypercalcemia: Treats elevated calcium levels by promoting its excretion.
Acute Pulmonary Edema: Provides rapid diuresis to alleviate fluid accumulation in the lungs.
Hyponatremia: Addresses low sodium levels through increased sodium excretion.