Bumetanide

Structure of Bumetanide

• Bumetanide is a loop diuretic similar to furosemide but with a more potent diuretic effect due to structural modifications.

• Chemical Formula: C₁₄H₂₄BrN₃O₅S

Structure of Bumetanide

Mode of Action

• Loop of Henle Inhibition: Blocks the Na⁺/K⁺/2Cl⁻ symporter in the ascending limb of the loop of Henle.

• Sodium, Potassium, Chloride Excretion: Promotes significant diuresis by increasing excretion of these ions.

• Calcium and Magnesium Retention: Enhances reabsorption of calcium and magnesium, reducing the risk of kidney stones.

Uses

1. Edema: Manages edema associated with congestive heart failure, renal disease, and liver cirrhosis.

2. Hypertension: Lowers blood pressure by reducing blood volume.

3. Hypercalcemia: Treats elevated calcium levels by promoting its excretion.

4. Acute Pulmonary Edema: Provides rapid diuresis to alleviate fluid accumulation in the lungs.

5. Hyponatremia: Addresses low sodium levels through increased sodium excretion.