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Busulfan

Structure of Busulfan

  • Busulfan is a bifunctional alkylating agent with two chloroethyl groups attached to a sulfur atom.

  • Chemical Formula: C₄H₈Cl₂NS

Mode of Action

  • DNA Alkylation: Forms interstrand and intrastrand crosslinks with DNA, disrupting replication and transcription.

  • Bone Marrow Suppression: Reduces bone marrow activity, which is useful in preparing for bone marrow transplants.

  • Inhibits Cell Division: Prevents proliferation of cancerous cells by damaging genetic material

Uses

  • Chronic Myeloid Leukemia (CML): As part of conditioning regimens before bone marrow transplantation.

  • Bone Marrow Transplantation: Used to ablate existing bone marrow.

  • Other Hematological Malignancies: Such as acute lymphoblastic leukemia (ALL)..



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