Busulfan

Structure of Busulfan

• Busulfan is a bifunctional alkylating agent with two chloroethyl groups attached to a sulfur atom.

• Chemical Formula: C₄H₈Cl₂NS

Structure of Busulfan

Mode of Action

• DNA Alkylation: Forms interstrand and intrastrand crosslinks with DNA, disrupting replication and transcription.

• Bone Marrow Suppression: Reduces bone marrow activity, which is useful in preparing for bone marrow transplants.

• Inhibits Cell Division: Prevents proliferation of cancerous cells by damaging genetic material

Uses

• Chronic Myeloid Leukemia (CML): As part of conditioning regimens before bone marrow transplantation.

• Bone Marrow Transplantation: Used to ablate existing bone marrow.

• Other Hematological Malignancies: Such as acute lymphoblastic leukemia (ALL)..