Structure of Busulfan
Busulfan is a bifunctional alkylating agent with two chloroethyl groups attached to a sulfur atom.
Chemical Formula: C₄H₈Cl₂NS
Mode of Action
DNA Alkylation: Forms interstrand and intrastrand crosslinks with DNA, disrupting replication and transcription.
Bone Marrow Suppression: Reduces bone marrow activity, which is useful in preparing for bone marrow transplants.
Inhibits Cell Division: Prevents proliferation of cancerous cells by damaging genetic material
Uses
Chronic Myeloid Leukemia (CML): As part of conditioning regimens before bone marrow transplantation.
Bone Marrow Transplantation: Used to ablate existing bone marrow.
Other Hematological Malignancies: Such as acute lymphoblastic leukemia (ALL)..