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CALCIUM CHANNEL BLOCKERS

  • CALCIUM CHANNEL BLOCKERS drugs used to treat angina pectoris, hypertension, and many other heart problems.

  • These drugs give their action by blocking calcium channel which inhibit the influx of Ca++ which is responsible for excitation, contraction, and secretion.

MECHANISM OF ACTION

  • The influx of Ca++ ions is caused by calcium channels.

  • Most of the Ca++ ions pass via the voltage gated L-type Calcium channel because it is more sensitive to voltage.

  • Sarcoplasmic reticulum is activated by these Ca++ ions, which leads to the production of more Ca++ ions. These Ca++ ions engage with the troponin-C receptor to cause actin and myosin to interact. which lead to additional contraction.

  • when a calcium channel blocker is introduced into the body.

  • These medications inhibit voltage-gated calcium channels of the L type. This further inhibits the influx of Ca++ ions.

  • That may result in a reduction in contraction and cause relaxation.

mechanism of action Ca++ channel blockers

EFFETCS OF CALCIUM CHANNEL BLOCKERS

  • Decrease in heart rate

  • Decrease in blood pressure

  • Decrease heart workload

  • Decrease in Oxygen demands

classification of Calcium Channel Blockers

Here is the diagram classifying the mentioned Calcium Channel Blockers:



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