CALCIUM CHANNEL BLOCKERS drugs used to treat angina pectoris, hypertension, and many other heart problems.
These drugs give their action by blocking calcium channel which inhibit the influx of Ca++ which is responsible for excitation, contraction, and secretion.
MECHANISM OF ACTION
The influx of Ca++ ions is caused by calcium channels.
Most of the Ca++ ions pass via the voltage gated L-type Calcium channel because it is more sensitive to voltage.
Sarcoplasmic reticulum is activated by these Ca++ ions, which leads to the production of more Ca++ ions. These Ca++ ions engage with the troponin-C receptor to cause actin and myosin to interact. which lead to additional contraction.
when a calcium channel blocker is introduced into the body.
These medications inhibit voltage-gated calcium channels of the L type. This further inhibits the influx of Ca++ ions.
That may result in a reduction in contraction and cause relaxation.
EFFETCS OF CALCIUM CHANNEL BLOCKERS
Decrease in heart rate
Decrease in blood pressure
Decrease heart workload
Decrease in Oxygen demands
Here is the diagram classifying the mentioned Calcium Channel Blockers:
