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Capreomycin sulfate: Chemical Structure, Mechanism of Action, Uses & Side effects

Chemical formula:

  • C25H44N14O8 (base); the sulfate salt has additional sulfate ions.

Structure of capreomycin Sulphat
Structure of capreomycin Sulphat

Mechanism of action:

  • Capreomycin is a cyclic peptide antibiotic that binds to the 23S rRNA of the 50S ribosomal subunit in bacteria, inhibiting protein synthesis.

Uses:

  • Capreomycin is used in combination with other antitubercular drugs for the treatment of multidrug-resistant tuberculosis (MDR-TB).

Side effects:

  • Side effects can include ototoxicity (hearing loss and vertigo), nephrotoxicity, electrolyte disturbances (e.g., hypokalemia


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