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Cetirizine

Structure of Cetirizine

Cetirizine is a metabolite of hydroxyzine with a piperazine ring substituted with a carboxylic acid group and an aromatic ring.

Chemical Formula: C₂₂H₂₁ClN₂O₃

Structure of Cetirizine
Structure of Cetirizine

Mode of Action

Selective peripheral H₁-receptor antagonist with minimal CNS penetration.

It effectively reduces histamine-induced symptoms with reduced sedation.

Uses

Allergic Rhinitis: Effective in treating symptoms like sneezing, itching, and runny nose.

Chronic Urticaria: Alleviates hives and skin itching.

Seasonal Allergies: Provides relief from pollen-induced allergic symptoms.


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