Structure of Cetirizine
Cetirizine is a metabolite of hydroxyzine with a piperazine ring substituted with a carboxylic acid group and an aromatic ring.
Chemical Formula: C₂₂H₂₁ClN₂O₃
Mode of Action
Selective peripheral H₁-receptor antagonist with minimal CNS penetration.
It effectively reduces histamine-induced symptoms with reduced sedation.
Uses
Allergic Rhinitis: Effective in treating symptoms like sneezing, itching, and runny nose.
Chronic Urticaria: Alleviates hives and skin itching.
Seasonal Allergies: Provides relief from pollen-induced allergic symptoms.