Chlorambucil

Structure of Chlorambucil

• Chlorambucil is an oral nitrogen mustard alkylating agent with a chlorinated alkyl chain.

• Chemical Formula: C₁₄H₁₄Cl₂N₂O₂

Structure of Chlorambucil

Mode of Action

• DNA Crosslinking: Forms covalent bonds with DNA, leading to crosslinks that inhibit DNA replication.

• Cell Cycle Arrest: Prevents cancer cells from progressing through the cell cycle.

• Apoptosis Induction: Causes programmed cell death in malignant cells.

Uses

• Chronic Lymphocytic Leukemia (CLL): Primary treatment option.

• Lymphomas: Such as Hodgkin's and non-Hodgkin's lymphoma.

• Breast Cancer: In combination with other chemotherapy agents