Structure of Chlorambucil
Chlorambucil is an oral nitrogen mustard alkylating agent with a chlorinated alkyl chain.
Chemical Formula: C₁₄H₁₄Cl₂N₂O₂
Mode of Action
DNA Crosslinking: Forms covalent bonds with DNA, leading to crosslinks that inhibit DNA replication.
Cell Cycle Arrest: Prevents cancer cells from progressing through the cell cycle.
Apoptosis Induction: Causes programmed cell death in malignant cells.
Uses
Chronic Lymphocytic Leukemia (CLL): Primary treatment option.
Lymphomas: Such as Hodgkin's and non-Hodgkin's lymphoma.
Breast Cancer: In combination with other chemotherapy agents