Chlorambucil

Structure

• Chlorambucil Chemical Structure – C14H19Cl2NO2

Mode of action

• Work through three distinct mechanisms:

I.   Alkyl groups are attached to DNA bases, causing repair enzymes to fragment the DNA to replace the alkylated bases, which prevents DNA synthesis and RNA transcription from the damaged DNA.

II.  DNA damage via the formation of cross-links which prevents DNA from being separated for synthesis or transcription

III. The production of incorrect nucleotide pairing, which results in mutations.

Uses

• Used to treat malignant lymphomas and chronic lymphocytic leukaemia.