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Chlorambucil

Structure of Chlorambucil

  • Chlorambucil is an oral nitrogen mustard alkylating agent with a chlorinated alkyl chain.

  • Chemical Formula: C₁₄H₁₄Cl₂N₂O₂

Structure of Chlorambucil
Structure of Chlorambucil

Mode of Action

  • DNA Crosslinking: Forms covalent bonds with DNA, leading to crosslinks that inhibit DNA replication.

  • Cell Cycle Arrest: Prevents cancer cells from progressing through the cell cycle.

  • Apoptosis Induction: Causes programmed cell death in malignant cells.

Uses

  • Chronic Lymphocytic Leukemia (CLL): Primary treatment option.

  • Lymphomas: Such as Hodgkin's and non-Hodgkin's lymphoma.

  • Breast Cancer: In combination with other chemotherapy agents


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