Chlorpheniramine maleate

Structure

• Chlorpheniramine maleate is a first-generation antihistamine with a dibenzyl structure connected to an ethylamine chain.

• It forms a salt with maleic acid to enhance solubility.

• Chemical Formula: C₁₇H₂₈ClN₃·C₄H₄O₄

Structure Chlorpheniramine maleate

Mode of Action

• Blocks H₁-receptors both peripherally and centrally, reducing allergic symptoms.

• Exhibits anticholinergic and sedative effects.

Uses of Action

• Allergic Rhinitis: Relieves symptoms such as sneezing, itching, and runny nose.

• Urticaria: Alleviates hives and skin itching.

• Cold Symptoms: Helps reduce nasal congestion and other cold-related symptoms.