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Chlorpropamide

Structure

  • Chlorpropamide is a second-generation sulfonylurea with chlorinated aromatic rings, enhancing its potency compared to first-generation agents.

  • Chemical Formula: C₁₇H₂₄ClN₃O₃S

Structure of Chlorpropamide
Structure of Chlorpropamide

Mode of Action

  • Similar to Tolbutamide: Blocks K⁺ channels, promotes insulin secretion.

  • Longer Duration: Provides extended insulinotropic effects.

Uses

  • Type 2 Diabetes Mellitus: Maintains blood glucose levels by increasing insulin secretion.

  • Gestational Diabetes: Used under strict medical supervision.


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