Structure of Cisplatin
Cisplatin is a platinum-based chemotherapeutic agent with a square planar geometry, featuring two chloride ligands and two amine groups bound to a central platinum atom.
Chemical Formula: C₆H₁₈Cl₂N₄Pt
Mode of Action
DNA Crosslinking: Forms intrastrand and interstrand crosslinks in DNA, disrupting DNA replication and transcription.
DNA Repair Inhibition: Prevents cancer cells from repairing DNA damage.
Apoptosis Induction: Leads to programmed cell death in malignant cells.
Uses
Testicular Cancer: Highly effective, often leading to cures.
Ovarian Cancer: As part of combination chemotherapy regimens.
Bladder Cancer: In combination with other chemotherapeutic agents.
Lung Cancer: Particularly non-small cell lung carcinoma.
Head and Neck Cancers: As part of multi-agent chemotherapy.eck, mouth, lip, cheek, tongue, palate, throat, tonsils, sinuses, lung, cervix, oesophagus, and brain tumours.