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Cisplatin

Structure of Cisplatin

  • Cisplatin is a platinum-based chemotherapeutic agent with a square planar geometry, featuring two chloride ligands and two amine groups bound to a central platinum atom.

  • Chemical Formula: C₆H₁₈Cl₂N₄Pt

    Structure of Cisplatin
    Structure of Cisplatin

Mode of Action

  • DNA Crosslinking: Forms intrastrand and interstrand crosslinks in DNA, disrupting DNA replication and transcription.

  • DNA Repair Inhibition: Prevents cancer cells from repairing DNA damage.

  • Apoptosis Induction: Leads to programmed cell death in malignant cells.

Uses

  1. Testicular Cancer: Highly effective, often leading to cures.

  2. Ovarian Cancer: As part of combination chemotherapy regimens.

  3. Bladder Cancer: In combination with other chemotherapeutic agents.

  4. Lung Cancer: Particularly non-small cell lung carcinoma.

  5. Head and Neck Cancers: As part of multi-agent chemotherapy.eck, mouth, lip, cheek, tongue, palate, throat, tonsils, sinuses, lung, cervix, oesophagus, and brain tumours.


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