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Clemastine fumarate

BP-S-5-MEDICINAL CHEMISTRY
1 min read

Structure

  • Clemastine fumarate is a first-generation antihistamine featuring a piperidine ring substituted with a dibenzocycloheptene moiety.

  • It forms a salt with fumaric acid to enhance stability.

  • Chemical Formula: C₂₀H₂₇NO₂·C₄H₆O₄


Structure Clemastine fumarate
Structure Clemastine fumarate

Mode of Action

  • Blocks peripheral H₁ receptors to reduce allergic responses.

  • Exhibits minimal penetration of the blood-brain barrier compared to other first-generation antihistamines, resulting in less sedation.

Uses of Clemastine fumarate

  • Allergic Rhinitis: Treats symptoms like sneezing, itching, and runny nose.

  • Urticaria: Relieves hives and skin itching.

  • Cold Symptoms: Helps reduce nasal congestion and runny nose.


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