Structure (Clemastine fumarate)
Clemastine fumarate is a first-generation antihistamine featuring a piperidine ring substituted with a dibenzocycloheptene moiety.
It forms a salt with fumaric acid to enhance stability.
Chemical Formula: C₂₀H₂₇NO₂·C₄H₆O₄
Mode of Action
Blocks peripheral H₁ receptors to reduce allergic responses.
Exhibits minimal penetration of the blood-brain barrier compared to other first-generation antihistamines, resulting in less sedation.
Uses
Allergic Rhinitis: Treats symptoms like sneezing, itching, and runny nose.
Urticaria: Relieves hives and skin itching.
Cold Symptoms: Helps reduce nasal congestion and runny nose.