Clemastine fumarate

Structure

• Clemastine fumarate is a first-generation antihistamine featuring a piperidine ring substituted with a dibenzocycloheptene moiety.

• It forms a salt with fumaric acid to enhance stability.

• Chemical Formula: C₂₀H₂₇NO₂·C₄H₆O₄

Structure Clemastine fumarate

Mode of Action

• Blocks peripheral H₁ receptors to reduce allergic responses.

• Exhibits minimal penetration of the blood-brain barrier compared to other first-generation antihistamines, resulting in less sedation.

Uses of Clemastine fumarate

• Allergic Rhinitis: Treats symptoms like sneezing, itching, and runny nose.

• Urticaria: Relieves hives and skin itching.

• Cold Symptoms: Helps reduce nasal congestion and runny nose.