Chemical formula:
C18H33ClN2O5S
Mechanism of action:
Clindamycin works by binding to the 50S subunit of the bacterial ribosome and inhibiting bacterial protein synthesis.
It prevents the elongation of the growing polypeptide chain by blocking the formation of peptide bonds between amino acids.
Clindamycin also inhibits the transcription of bacterial DNA by binding to bacterial RNA polymerase.
Uses:
Clindamycin is used to treat a wide range of bacterial infections, including skin and soft tissue infections, respiratory tract infections, bone and joint infections, and infections of the female reproductive tract.
It is also used as a prophylactic agent to prevent bacterial endocarditis in patients with certain heart conditions.
Side effects:
Clindamycin is associated with several side effects, including gastrointestinal disturbances, such as nausea, vomiting, and diarrhea.
It can also cause allergic reactions, including skin rashes and anaphylaxis.
In rare cases, clindamycin can cause a serious condition called Clostridium difficile-associated diarrhea, which can be fatal.
Clindamycin should be used with caution in patients with a history of gastrointestinal disease or allergies