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Clofibrate

Structure

  • Clofibrate is a fibrate derivative with a benzofurazan core structure, characterized by two chlorine atoms and a carboxylic acid group.

  • Chemical Formula: C₁₄H₁₉Cl₂N₃O₄S

    Chemical Formula of Clofibrate
Structure of Clofibrate
Structure of Clofibrate

Mode of Action

  • PPAR-α Agonist: Activates peroxisome proliferator-activated receptor alpha (PPAR-α), regulating lipid metabolism.

  • Triglyceride Reduction: Enhances the oxidation of fatty acids, leading to decreased triglyceride levels.

  • HDL-C Increase: Increases high-density lipoprotein cholesterol (HDL-C) levels.

  • VLDL-C Reduction: Lowers very-low-density lipoprotein cholesterol (VLDL-C) levels by reducing hepatic secretion.

Uses of Clofibrate

  • Hypertriglyceridemia: Lowers elevated triglyceride levels in the blood.

  • Dyslipidemia: Manages abnormal lipid profiles by reducing total cholesterol and LDL-C levels.

  • Prevention of Atherosclerosis: Reduces the risk of atherosclerotic cardiovascular diseases by improving lipid profiles.


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