Structure
Clofibrate Chemical Structure – C12H15ClO3
Mode of action
Blood triglyceride and cholesterol levels are reduced by clofibrate.
The extrahepatic lipoprotein lipase activity is increased by clofibrate, which also increases lipoprotein triglyceride lipolysis.
Chylomicrons are broken down, VLDLs (very low-density lipoprotein) are changed into LDLs (low density lipoprotein), and LDLs into HDL.
This is followed by a small increase in the secretion of lipids into the bile, which further enters the intestine.
Uses
Hypertriglyceridemia and high cholesterol are both conditions that are treated with clofibrate.