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Clonidine hydrochloride

Structure of Clonidine hydrochloride

  • Clonidine hydrochloride is an imidazoline derivative with a chlorinated aromatic ring and an imidazoline core.

  • Chemical Formula: C₉H₉ClN₂ · HCl

Structure of Clonidine hydrochloride
Structure of Clonidine hydrochloride

Mode of Action

  • Alpha-2 Adrenergic Agonism: Activates central alpha-2 receptors in the brainstem.

  • Sympathetic Inhibition: Decreases sympathetic outflow, reducing peripheral vascular resistance and lowering blood pressure.

  • Analgesic Effects: Modulates pain perception through central mechanisms.

Uses

  1. Hypertension: Manages high blood pressure by reducing sympathetic tone.

  2. ADHD: Used as an adjunctive therapy for attention-deficit/hyperactivity disorder.

  3. Opioid Withdrawal: Alleviates withdrawal symptoms by reducing sympathetic hyperactivity.

  4. Anxiety Disorders: Provides calming effects and reduces anxiety.

  5. Pain Management: Employed in chronic pain conditions for its analgesic properties.


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