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Clopidogrel

Structure

  • Clopidogrel is a thienopyridine class antiplatelet agent featuring a thiophene ring attached to a pyridine moiety with a chlorophenyl group.

  • Chemical Formula: C₁₅H₁₂ClNO₂S

    Chemical formula of Clopidogrel
Structure of Clopidogrel
Structure of Clopidogrel

Mode of Action

  • P2Y₁₂ Receptor Inhibition: Irreversibly blocks the P2Y₁₂ ADP receptor on platelet cell membranes.

  • Platelet Aggregation Prevention: Inhibits ADP-mediated activation of glycoprotein GPIIb/IIIa, preventing fibrinogen binding and platelet aggregation.

  • Thrombus Prevention: Reduces the formation of blood clots in arteries and veins.

Uses of Clopidogrel

  • Acute Coronary Syndrome (ACS): Reduces the risk of heart attack and stroke in patients with ACS.

  • Percutaneous Coronary Intervention (PCI): Prevents stent thrombosis in patients undergoing PCI.

  • Secondary Prevention of Myocardial Infarction and Ischemic Stroke: Lowers the risk of recurrent cardiovascular events.

  • Peripheral Artery Disease (PAD): Manages and prevents thrombotic complications in PAD patients.


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