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Colestipol

Structure

  • Colestipol is a non-absorbed, cross-linked polyallylamine derivative with quaternary ammonium groups, functioning as a bile acid sequestrant.

  • Chemical Formula: (C₃H₇NCl)ₙ·(C₇H₁₅O₄S)ₙ

    Chemical formula of Colestipol
Structure of Colestipol
Structure of Colestipol

Mode of Action

  • Bile Acid Sequestration: Binds bile acids in the gastrointestinal tract, preventing their reabsorption.

  • Cholesterol Synthesis Reduction: Increases the conversion of cholesterol to bile acids in the liver.

  • LDL-C Lowering: Enhances clearance of LDL-C from the bloodstream by upregulating hepatic LDL receptors.

Uses of Colestipol

  • Hypercholesterolemia: Reduces LDL-C and total cholesterol levels.

  • Type 2 Diabetes Mellitus: Used in combination with insulin or other hypoglycemic agents to manage hyperlipidemia.

  • Diarrhea Management: Treats bile acid-induced diarrhea by sequestering excess bile acids.


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