Compression is the final step in tablet manufacturing, where granules are pressed into solid tablets using a tablet press.
Several challenges can arise during compression:
Compression Problems:
Capping: Tablet top or bottom separates due to low tensile strength or high compression force.
Lamination: Splitting into layers caused by uneven stress distribution.
Picking/Sticking: Material adheres to punches, causing incomplete tablets and contamination.
Mottling: Uneven color distribution due to inconsistent mixing.
Elastic Rebound: Tablets expand after compression, reducing hardness.
Erosion: Surface material loss leads to weight variation.
Processing Problems:
Poor Flowability: Uneven feeding causes weight variation.
Dust Formation: Material loss and inhalation hazards.
Moisture Issues: Stickiness affects hardness and disintegration.
Temperature Control: Heat-sensitive drugs may degrade.
Equipment Wear: Punches and dies wear out, reducing tablet quality.