Structure
Cortisone is a synthetic corticosteroid with a cyclopentanoperhydrophenanthrene structure, featuring hydroxyl and keto functional groups.
Chemical Formula: C₂₂H₂₈O₅
Mode of Action
Glucocorticoid Activity: Binds to glucocorticoid receptors, regulating gene expression involved in inflammatory and immune responses.
Anti-Inflammatory Effects: Reduces inflammation by inhibiting pro-inflammatory cytokines and mediators.
Immunosuppression: Suppresses the immune system, reducing hypersensitivity and autoimmune responses.
Uses
Inflammatory Conditions: Treats arthritis, asthma, and allergic reactions by reducing inflammation.
Autoimmune Diseases: Manages conditions like lupus and multiple sclerosis through immunosuppression.
Endocrine Disorders: Used in adrenal insufficiency to replace deficient cortisol.
Skin Conditions: Applied topically to treat dermatitis, eczema, and psoriasis.