Cortisone

Structure

• Cortisone is a synthetic corticosteroid with a cyclopentanoperhydrophenanthrene structure, featuring hydroxyl and keto functional groups.

• Chemical Formula: C₂₂H₂₈O₅

Structure of Cortisone

Mode of Action

• Glucocorticoid Activity: Binds to glucocorticoid receptors, regulating gene expression involved in inflammatory and immune responses.

• Anti-Inflammatory Effects: Reduces inflammation by inhibiting pro-inflammatory cytokines and mediators.

• Immunosuppression: Suppresses the immune system, reducing hypersensitivity and autoimmune responses.

Uses

• Inflammatory Conditions: Treats arthritis, asthma, and allergic reactions by reducing inflammation.

• Autoimmune Diseases: Manages conditions like lupus and multiple sclerosis through immunosuppression.

• Endocrine Disorders: Used in adrenal insufficiency to replace deficient cortisol.

• Skin Conditions: Applied topically to treat dermatitis, eczema, and psoriasis.