Coulson and Moffitt’s Modification
- S-3-PHARMACEUTICAL-ORGANIC-CHEMISTRY
- Feb 28
- 1 min read
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Introduction
Coulson and Moffitt, in 1947, modified Baeyer’s theory by introducing the concept of non-planar ring structures, particularly for cyclohexane.
Key Concepts of Coulson and Moffitt’s
Non-Planar Structures
They proposed that cyclohexane is not planar but rather adopts non-planar structures like the chair and boat conformations, which relieve angle strain.
Bond Angle Deformation
Coulson and Moffitt introduced the idea that bond angles in larger rings can deviate slightly from the ideal tetrahedral angle without causing significant strain.
Stability Explanation
Cyclohexane
Cyclohexane is most stable in the chair conformation, where the bond angles are very close to 109.5°, and there is no angle strain.
The boat conformation, while less stable, also demonstrates that cyclohexane can adopt various non-planar forms to relieve strain.
Larger Rings
For rings larger than cyclohexane, Coulson and Moffitt's modification explains that they can adopt puckered or twisted conformations, reducing angle strain.
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