Cycloguanil Pamoate
- BP-S-6-Medicinal Chemistry III
- Mar 28
- 1 min read
Chemical Structure / Formula of Cycloguanil Pamoate
Formula: C17H19N5
Structure: A dihydrotriazine derivative, the active metabolite of proguanil.
Mechanism of Action
Inhibits dihydrofolate reductase (DHFR) in Plasmodium, preventing DNA synthesis and replication.
Uses
Treatment and prophylaxis of malaria (P. falciparum, P. vivax).
Often used in combination with sulfonamides.
Side Effects
GI disturbances, skin rash.
Megaloblastic anemia (rare, seen in folate-deficient patients).
