Structure of Cyclothiazide
Cyclothiazide is a thiazide diuretic with a cyclohexane ring substitution, differing structurally from other thiazides.
Chemical Formula: C₁₂H₁₅ClN₃O₄S₂
Structure of Cyclothiazide
Mode of Action
Thiazide Receptor Blocking: Inhibits the sodium-chloride symporter in the distal convoluted tubule.
Sodium and Chloride Excretion: Promotes diuresis by increasing the excretion of sodium and chloride ions.
Potassium Loss: Enhances excretion of potassium and hydrogen ions, potentially causing hypokalemia and metabolic alkalosis.
Uses
Hypertension: Utilized to reduce blood pressure through diuretic and vasodilatory effects.
Edema: Treats fluid retention in conditions such as congestive heart failure, liver cirrhosis, and renal disorders.
Nephrolithiasis Prevention: Assists in preventing calcium-containing kidney stones.
Heart Failure: Part of diuretic therapy to manage edema and reduce cardiac workload.