Structure of Daunorubicin
Daunorubicin is an anthracycline antibiotic characterized by a tetracyclic ring structure with a daunosamine sugar moiety.
Chemical Formula: C₂₄H₂₈N₂O₁₃
Mode of Action
DNA Intercalation: Inserts between DNA base pairs, disrupting DNA replication and transcription.
Topoisomerase II Inhibition: Prevents the re-ligation of DNA strands, leading to DNA breaks.
Free Radical Formation: Generates reactive oxygen species, causing cellular damage.
Uses
Acute Myeloid Leukemia (AML): Particularly effective in combination with cytarabine.
Acute Lymphoblastic Leukemia (ALL): In pediatric and adult populations.
Chronic Myeloid Leukemia (CML): In certain treatment protocols.
Lymphomas: Including Hodgkin's and non-Hodgkin's lymphoma.
