Diazoxide

Structure of Diazoxide

• Diazoxide is a benzothiadiazine derivative with an open ring structure, containing a sulfonamide group and a hydroxyl substituent.

• Chemical Formula: C₈H₇N₃O₃S

Structure of Diazoxide

Mode of Action

• Potassium Channel Opener: Activates ATP-sensitive potassium channels in vascular smooth muscle.

• Hyperpolarization: Causes hyperpolarization of smooth muscle cells, leading to vasodilation.

• Insulin Release Inhibition: Suppresses insulin secretion from pancreatic beta cells.

Uses

1. Hypertension: Induces vasodilation in hypertensive patients.

2. Hypoglycemia: Prevents insulin-induced hypoglycemia by inhibiting insulin release.

3. Hyperinsulinism: Manages conditions with excessive insulin secretion.

4. Hypertensive Crises: Provides rapid blood pressure reduction in acute settings.