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Diazoxide

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Structure of Diazoxide

  • Diazoxide is a benzothiadiazine derivative with an open ring structure, containing a sulfonamide group and a hydroxyl substituent.

  • Chemical Formula: C₈H₇N₃O₃S

Structure of Diazoxide
Structure of Diazoxide

Mode of Action

  • Potassium Channel Opener: Activates ATP-sensitive potassium channels in vascular smooth muscle.

  • Hyperpolarization: Causes hyperpolarization of smooth muscle cells, leading to vasodilation.

  • Insulin Release Inhibition: Suppresses insulin secretion from pancreatic beta cells.

Uses

  1. Hypertension: Induces vasodilation in hypertensive patients.

  2. Hypoglycemia: Prevents insulin-induced hypoglycemia by inhibiting insulin release.

  3. Hyperinsulinism: Manages conditions with excessive insulin secretion.

  4. Hypertensive Crises: Provides rapid blood pressure reduction in acute settings.


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