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Dibucaine

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Structure

  • Dibucaine is a potent amino benzoic acid derivative with a butyl ester group, providing long-lasting local anesthetic effects.

  • Chemical Formula: C₁₀H₂₀N₂O₂

    formula of Dibucaine
Structure of Dibucaine
Structure of Dibucaine

Mode of Action

  • Sodium Channel Blockade: Inhibits voltage-gated sodium channels, preventing nerve impulse conduction.

  • Membrane Stabilization: Enhances nerve membrane stability, reducing excitability.

Uses

  • Topical Anesthesia: Applied in rectal preparations, hemorrhoid treatments, and skin procedures for prolonged numbing.

  • Local Anesthesia: Used in minor surgical procedures requiring extended anesthesia.

  • Dermatological Applications: Employed in creams and ointments for skin conditions requiring local pain relief.

Side Effects

  • Local Irritation: Redness, swelling, or discomfort at the application site.

  • Systemic Toxicity: CNS excitation (e.g., seizures) and cardiovascular disturbances in high doses.


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