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Dichlorphenamide

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Structure of Dichlorphenamide

  • Dichlorphenamide is a sulfonamide derivative with two chlorine atoms attached to the benzene ring and a central sulfonamide group.

  • Chemical Formula: C₆H₇Cl₂N₃O₃S₂

Structure of Dichlorphenamide
Structure of Dichlorphenamide

Mode of Action

  • Carbonic Anhydrase Inhibition: Blocks carbonic anhydrase activity, reducing bicarbonate reabsorption in the kidneys.

  • Renal Effects: Promotes excretion of bicarbonate, sodium, potassium, and water, leading to diuresis.

  • Metabolic Acidosis: Induces mild metabolic acidosis by lowering bicarbonate levels.

Uses

  1. Glaucoma: Lowers intraocular pressure by decreasing aqueous humor production.

  2. Epilepsy: Acts as an adjunctive therapy in seizure management.

  3. Idiopathic Intracranial Hypertension: Reduces intracranial pressure.

  4. Diuretic: Used in conditions requiring carbonic anhydrase inhibition.


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