Structure of Dichlorphenamide
Dichlorphenamide is a sulfonamide derivative with two chlorine atoms attached to the benzene ring and a central sulfonamide group.
Chemical Formula: C₆H₇Cl₂N₃O₃S₂
Mode of Action
Carbonic Anhydrase Inhibition: Blocks carbonic anhydrase activity, reducing bicarbonate reabsorption in the kidneys.
Renal Effects: Promotes excretion of bicarbonate, sodium, potassium, and water, leading to diuresis.
Metabolic Acidosis: Induces mild metabolic acidosis by lowering bicarbonate levels.
Uses
Glaucoma: Lowers intraocular pressure by decreasing aqueous humor production.
Epilepsy: Acts as an adjunctive therapy in seizure management.
Idiopathic Intracranial Hypertension: Reduces intracranial pressure.
Diuretic: Used in conditions requiring carbonic anhydrase inhibition.