Dichlorphenamide

Structure of Dichlorphenamide

• Dichlorphenamide is a sulfonamide derivative with two chlorine atoms attached to the benzene ring and a central sulfonamide group.

• Chemical Formula: C₆H₇Cl₂N₃O₃S₂

Structure of Dichlorphenamide

Mode of Action

• Carbonic Anhydrase Inhibition: Blocks carbonic anhydrase activity, reducing bicarbonate reabsorption in the kidneys.

• Renal Effects: Promotes excretion of bicarbonate, sodium, potassium, and water, leading to diuresis.

• Metabolic Acidosis: Induces mild metabolic acidosis by lowering bicarbonate levels.

Uses

1. Glaucoma: Lowers intraocular pressure by decreasing aqueous humor production.

2. Epilepsy: Acts as an adjunctive therapy in seizure management.

3. Idiopathic Intracranial Hypertension: Reduces intracranial pressure.

4. Diuretic: Used in conditions requiring carbonic anhydrase inhibition.