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Didanosine (ddI)

Chemical Structure / Formula of Didanosine

  • Formula: C10H12N4O3

  • Structure: A purine nucleoside analog (dideoxyinosine) lacking a 3'-OH group.

Chemical Structure of Didanosine (ddl)

Mechanism of Action

  • Converted into Didanosine triphosphate, which inhibits HIV reverse transcriptase.

  • Causes chain termination due to lack of 3'-OH group.

Uses

  • HIV/AIDS therapy (HAART regimen).

Side Effects

  • Pancreatitis (dose-dependent, severe).

  • Peripheral neuropathy, lactic acidosis.

  • Hepatotoxicity, diarrhea.


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Chemical Structure / Formula of Zidovudine (AZT) Formula:  C10H13N5O4 Structure:  A thymidine analog  with an azido (-N3) group at C3 ....

 
 
 
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