Structure
Digoxin is a cardiac glycoside derived from the foxglove plant, featuring a steroid nucleus linked to a lactone ring and a sugar moiety.
Chemical Formula: C₄₈H₇₂O₁₉
Mode of Action
Na⁺/K⁺-ATPase Inhibition: Binds to the sodium-potassium pump, inhibiting its activity.
Intracellular Sodium Increase: Leads to increased intracellular calcium via the sodium-calcium exchanger.
Positive Inotropic Effect: Enhances cardiac contractility by increasing calcium availability in cardiac myocytes.
Vagal Stimulation: Increases vagal tone, reducing heart rate and AV node conduction.
Uses
Heart Failure: Improves cardiac output and symptoms in systolic heart failure.
Atrial Fibrillation and Flutter: Controls ventricular rate by enhancing vagal tone.
Supraventricular Tachycardias: Manages rapid heart rhythms by slowing AV node conduction.
Digitalis Toxicity: Monitors and manages symptoms of digoxin toxicity.