Diltiazem hydrochloride

Structure of Diltiazem hydrochloride

• Diltiazem hydrochloride is a benzothiazepine derivative with an imidazole ring fused to a thiazepine ring, attached to methoxy and ethyl substituents.

• Chemical Formula: C₂₀H₂₄N₂O₄S·HCl

Structure of Diltiazem hydrochloride

Mode of Action

• Calcium Channel Blocking: Inhibits L-type calcium channels in cardiac and smooth muscle.

• Negative Inotropic Effect: Decreases myocardial contractility.

• Negative Chronotropic Effect: Slows heart rate by affecting sinoatrial and atrioventricular nodes.

• Vasodilation: Relaxes vascular smooth muscle, reducing blood pressure.

Uses

1. Hypertension: Lowers blood pressure through vasodilation.

2. Angina Pectoris: Alleviates chest pain by reducing myocardial oxygen demand.

3. Supraventricular Tachycardia: Manages certain types of rapid heart rhythms.

4. Arrhythmias: Treats various cardiac arrhythmias.

5. Hypertrophic Obstructive Cardiomyopathy: Reduces ventricular outflow tract obstruction.