Dimenhydrinate

Structure

• Dimenhydrinate is a combination of diphenhydramine and 8-chlorotheophylline.

• It forms a hydrate salt, enhancing its pharmacokinetic properties.

• Chemical Formula: C₁₉H₂₆ClN₃O·H₂O

dipehnhyframine, 8-chlorotheophylline

• It’s a combination of Diphenhydramine and 8-chlorotheophylline.

Mode of action

• Acts primarily as an H₁-antagonist to reduce histamine-induced symptoms.

• The theophylline component provides mild stimulant effects to counteract diphenhydramine-induced sedation, making it effective for motion sickness.

Synthesis

Synthesis

Uses of Dimenhydrinate

• Motion Sickness: Prevents and treats nausea, vomiting, and dizziness associated with travel.

• Vertigo: Alleviates symptoms of vertigo and balance disorders.

• Allergic Reactions: Provides relief from allergic symptoms with reduced sedation