Diphenoxylate Hydrochloride: Chemical Structure, Mechanism of Action, Uses & Side Effects

Chemical Structure:

• C30H32N2O2 · HCl

Chemical Structure

Mechanism of Action:

• ·        Acts on mu-opioid receptors in the intestine, reducing gut motility and allowing more time for fluid absorption, which helps solidify stool.

Uses:

• Diarrhea Treatment: Often combined with atropine (as in Lomotil) to reduce abuse potential.

Side Effects:

• Central Effects at High Doses: Euphoria and CNS depression (rare due to atropine in the formulation).

• Gastrointestinal Issues: Including constipation and abdominal discomfort.