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Diphenoxylate Hydrochloride: Chemical Structure, Mechanism of Action, Uses & Side Effects

Chemical Structure:

  • C30H32N2O2 · HCl

Chemical Structure
Chemical Structure

Mechanism of Action:

  • ·        Acts on mu-opioid receptors in the intestine, reducing gut motility and allowing more time for fluid absorption, which helps solidify stool.

Uses:

  • Diarrhea Treatment: Often combined with atropine (as in Lomotil) to reduce abuse potential.

Side Effects:

  • Central Effects at High Doses: Euphoria and CNS depression (rare due to atropine in the formulation).

  • Gastrointestinal Issues: Including constipation and abdominal discomfort.

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