Dipyridamole

Structure of Dipyridamole

• Dipyridamole is a bis(pyrrolidine) derivative linked by a central ethylene bridge with two methanol side groups.

• Chemical Formula: C₂₀H₂₂N₄O₂

Structure of Dipyridamole

Mode of Action

• Phosphodiesterase Inhibition: Inhibits the enzyme responsible for breaking down cyclic AMP and cyclic GMP, increasing their intracellular levels.

• Vasodilation: Enhances nitric oxide-mediated vasodilation.

• Antiplatelet Effects: Inhibits platelet aggregation by increasing cyclic AMP in platelets.

• Inhibition of Adenosine Reuptake: Prolongs the action of adenosine, leading to vasodilation and anti-inflammatory effects.

Uses

1. Stroke Prevention: Reduces the risk of stroke in patients with a history of transient ischemic attacks or ischemic strokes.

2. Thrombosis Prevention: Used in combination with other antiplatelet agents to prevent clot formation.

3. Coronary Artery Disease: Enhances blood flow and reduces platelet aggregation.

4. Peripheral Arterial Disease: Improves blood circulation in affected limbs.