top of page
Search

Dipyridamole

Structure of Dipyridamole

  • Dipyridamole is a bis(pyrrolidine) derivative linked by a central ethylene bridge with two methanol side groups.

  • Chemical Formula: C₂₀H₂₂N₄O₂

Structure of Dipyridamole
Structure of Dipyridamole

Mode of Action

  • Phosphodiesterase Inhibition: Inhibits the enzyme responsible for breaking down cyclic AMP and cyclic GMP, increasing their intracellular levels.

  • Vasodilation: Enhances nitric oxide-mediated vasodilation.

  • Antiplatelet Effects: Inhibits platelet aggregation by increasing cyclic AMP in platelets.

  • Inhibition of Adenosine Reuptake: Prolongs the action of adenosine, leading to vasodilation and anti-inflammatory effects.

Uses

  1. Stroke Prevention: Reduces the risk of stroke in patients with a history of transient ischemic attacks or ischemic strokes.

  2. Thrombosis Prevention: Used in combination with other antiplatelet agents to prevent clot formation.

  3. Coronary Artery Disease: Enhances blood flow and reduces platelet aggregation.

  4. Peripheral Arterial Disease: Improves blood circulation in affected limbs.



bottom of page